Faculty of Veterinary Science Research areas

Staff Profile:

Photograph of Professor Marshall Lightowlers

Professor Marshall Lightowlers

Professor Marshall Lightowlers BSc (Hons), PhD (West Aust)
Professor and Principal Research Fellow with the National Health and
Medical Research Council

Professor Marshall Lightowlers commenced employment with the Faculty of Veterinary Science in 1981, as a senior post-doctoral fellow and became head of the cestode vaccine molecular parasitology unit in 1989. He had previously been employed as a post-doctoral scientist at the Institute of Medical and Veterinary Science in Adelaide, South Australia. Professor Lightowlers was awarded the Bancroft-Mackerras Medal of The Australian Society for Parasitology in 1998 for 'an outstanding contribution to the science of parasitology' (citation published in International Journal for Parasitology 29: 809-810, 1999).

Contact details:
Telephone: +61 3 9731 2284
Facsimile: +61 3 9741 5461
Email form: click to contact

Field of Expertise:
Molecular parasitology and vaccine development

Research Interests:
Development of recombinant vaccines to prevent cysticercosis and hydatid disease in domestic animals and humans.

Immunology and molecular biology of cestode parasites.

Diagnosis of hydatid disease.

Current Research Projects:
Cloning and expression of oncosphere antigens of Taenia solium towards the development of a practical vaccine to prevent the transmission of human neurocysticercosis.

Immunological and molecular analysis of the EG95 vaccine for prevention of hydatid disease.

Application of peptide mimotope phage display technology for the study of conformational host protective epitopes of Echinococcus granulosus EG95.

Development of strategies for delivery of edible vaccines.

Assessment of genetic variability in the EG95 gene family in Echinococcus granulosus.

Commercial scale-up and field trial testing of the TSA recombinant vaccine for the prevention of cysticercosis in cattle.

Vaccination against cysticercosis in sheep using recombinant oncosphere antigens.

Immunology and molecular aspects of cyclophilins in Echinococcus granulosus.

Committee Memberships:
Member of the University of Melbourne Postgraduate scholarships Committee,
Member of the Faculty of Veterinary Science's Veterinary Research and Graduate Studies Committee,
Coordinator NHMRC Grant Advisory Group 2 (GAG2 – Immunology, Microbiology, Inflammation, Tumor Immunology)

Member of Research Groups:
Parasitology and Cestode Vaccines (Research Leader)

Selected Publications:

VURAL, G., BACA, A.U., GAUCI, C.G., BAGCI, O., GICIK, Y. AND LIGHTOWLERS, M.W. (2008) Variability in the Echinococcus granulosus Cytochrome C oxidase 1 mitochondrial gene sequence from livestock in Turkey and a re-appraisal of the G1-3 genotype cluster. Veterinary Parasitology 154: 347-50.

GAUCI, C., VURAL, G., ONCEL, T., VARCASIA, A., DAMIAN, V., KYNGDON, C.T., CRAIG, P.S., ANDERSON, G.A. AND LIGHTOWLERS, M.W. (2008) Vaccination with recombinant oncosphere antigens reduces the susceptibility of sheep to infection with Taenia multiceps. International Journal fort Parasitology 38:1041-1050.

CRAIG, P.S., MCMANUS, D.P., LIGHTOWLERS, M.W., CHABALGOITY, J.A., GARCIA, H.H., GAVIDIA, C.M., GILMAN, R.H., GONZALEZ, A.E., LORCA, M., NAQUIRA, C., NIETO, A. & SCHANTZ, P.M. 2007. Prevention and control of cystic echinococcosis. Lancet Infectious Disease 7: 385-94.

GAUCI, C.G., VERASTEGUI, M.R., GILMAN, R.H. & LIGHTOWLERS, M.W. (2006) Taenia solium and Taenia ovis: stage-specific expression of the vaccine antigen genes, TSOL18, TSOL16, and homologues, in oncospheres. Experimental Parasitology 113: 272-275.

VARCASIA, A., LIGHTOWLERS, M.W., CATTOLI, G., CANCEDDA, G.M., CANU, S., GARIPPA, G. & SCALA, A. (2006) Genetic variation within Taenia multiceps in Sardinia, Western Mediterranean (Italy).Parasitology Research 99: 622-626.

LIGHTOWLERS, M.W. 2006. Cestode vaccines: origins, current status and future prospects. Parasitology 133: S27-S42.

LIGHTOWLERS, M.W. 2006. Vaccines against cysticercosis and hydatidosis: foundations in cestode immunology. Parasitology International, 55:S39-43.

KYNGDON, C.T., GAUCI, C.G., ROLFE, R.A., VELÁSQUEZ GUZMÁN, J.C., FARFÁN SALAZAR, M.J., VERÁSTEGUI PIMENTEL, M.R., GONZALEZ, A.E., GARCIA, H.H., GILMAN, R.H., STRUGNEL LR.A. & LIGHTOWLERS, M.W. 2006. In vitro oncosphere – killing assays to determine immunity to the larvae of Taenia pisiformis, Taenia ovis, Taenia saginata and Taenia solium. Journal of Parasitology, 92:273-281.

KYNGDON, C.T., GAUCI, C.G., GONZALEZ, A.E., FLISSER, A., ZOLI, A., READ, A.J., STRUGNELL, R.A. & LIGHTOWLERS, M.W. 2006. Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A. Parasite Immunology 28: 191-199.

LIGHTOWLERS, M.W. 2006. Cestode vaccine development. In Parasitic Flatworms: Molecular biology, biochemistry, Immunology and Control, A. Maule ed. CAB International, Wallingford, pp 282-302.

Further Publications: PubMed Search