Professor Eleanor Mackie
Staff Profile:
Professor Eleanor Mackie BVSc (Hons; Sydney) MS (Iowa State) Dr med vet (Zürich) MRCVS
Contact details:
Telephone: +61 3 8344 0357
Facsimile: +61 3 8344 7374
Email form: click to contact
Appointments:
Associate Dean – Academic Staff
Teaching Responsibilities:
250-204 Veterinary Physiology 2
Co-ordinator Roles:
First-year Co-ordinator
Field of Expertise:
Cell biology of musculoskeletal development and pathology
Research Interests:
Regulation of bone, cartilage and muscle cell function
Extracellular matrix
Thrombin and protease-activated receptors
Regulation of osteoblast and myoblast apoptosis
Current Research Projects:
The role of tenascins in bone and joint pathology
The role of protease-activated receptor-2 in regulation of bone metabolism
Cellular responses to thrombin in skeletal pathology
Bacterial proteases and the pathophysiology of periodontal disease
Pathophysiological mechanisms in equine dyschondroplasia (osteochondrosis)
Factors regulating myoblast differentiation
Committee Memberships:
Member of the Faculty of Veterinary Science's Course and Assessment Committee, the Executive Committee, the Planning and Resources Committee, the Selection Committee, the Unsatisfactory Progress Committee and the Veterinary Research and Graduate Studies Committee
Other Links:
Associate Professor Mackie is also a member of the Network in Genes and Environment in Development, which recently received ARC funding. For more information, see www.nged.adelaide.edu.au/
Member of Research Groups:
Bone and Muscle Cell Biology (Research Leader)
Selected Publications:
de Niese, M.R., Chinni, C., Pike, R.N., Bottomley, S.P. and Mackie, E.J. (2002) Dissection of protease-activated receptor-1-dependent and -independent responses to thrombin in skeletal myoblasts. Exp. Cell Res. 274:149-156.
Lourbakos, A., Potempa, J., Travis, J., D'Andrea M.R., Andrade-Gordon, P., Santulli, R., Mackie, E.J. and Pike, R.N. (2001) An arginine specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect. Immun. 69:5121-5130.
Chinni, C., de Niese, M.R., Jenkins, A.L., Pike, R.N., Bottomley, S.P. and Mackie, E.J. (2000) Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts. J. Cell Sci. 113:4427-4433.
Murphy, L.I., Fischer, D., Chiquet-Ehrismann, R. and Mackie, E.J. (2000) Tenascin-C induced stimulation of chondrogenesis is dependent on the presence of the C-terminal fibrinogen-like domain. FEBS Letters 480:189-192.
Abraham, L.A., Chinni, C., Jenkins, A.L., Lourbakos, A., Ally, N., Pike, R. N. and Mackie, E.J. (2000) Expression of protease-activated receptor-2 by osteoblasts. Bone 26:7-14.
Abraham, L.A. and Mackie, E.J. (1999) Modulation of osteoblast-like cell behaviour by activation of protease-activated receptor-1. J. Bone Miner. Res. 14:1320-1329.
Chinni, C., de Niese, M.R., Tew, D.J., Jenkins, A.L., Bottomley, S.P. and Mackie, E.J. (1999) Thrombin: A survival factor for myoblasts. J. Biol. Chem 274:9169-9174.
Abraham, L.A., Jenkins, A.L., Stone, S.R. and Mackie, E.J. (1998) Expression of the thrombin receptor in developing bone and associated tissues. J. Bone Miner. Res. 13:818-827.
Webb, C.M.B., Zaman, G., Mosley, J.R., Tucker, R.P., Lanyon, L.E. and Mackie, E.J. (1997) Expression of tenascin-C in bones responding to mechanical load. J. Bone Miner. Res. 12:52-58.
Mackie, E.J. and Ramsey, S. (1996) Modulation of osteoblast behaviour by tenascin. J. Cell Sci. 109:1597-1604.
Further Publications: PubMed Search